Micromotor-based lab-on-chip immunoassays

Micromotor-based lab-on-chip immunoassays.

Here we describe the first example of using self-propelled antibody-functionalized synthetic catalytic microengines for capturing and transporting target proteins between the different reservoirs of a lab-on-a-chip (LOC) device. A new catalytic polymer/Ni/Pt microtube engine, containing carboxy moieties on its mixed poly(3,4-ethylenedioxythiophene) (PEDOT)/COOH-PEDOT polymeric outermost layer, ...

Acoustically Driven Microfluidic Micromotor for Lab-on-a-microdisc

We report on the implementation of a novel surface acoustic wave driven fluid-coupled rotational micromotor. A pair of opposing surface acoustic waves were generated on a Lithium Niobate substrate, geometrically tailored to asymmetrically enter the water fluid coupling layer. This generated high rotational velocities in the fluid coupling layer and subsequently the disc. Rotation of a 5 mm diam...

Microfluidic Lab-on-a-chip System with Integrated Sample Preparation for Processing Immunoassays

We present an advanced, injection molded microfluidic lab-on-a-chip cartridge to process immunoassays with unit operations for sample preparation, metering, mixing, incubation, washing, chemiluminescence detection and waste handling. A newly developed readout device is capable of recording data points under rotation. Latest assay results feature a lower average standard deviation (7 % of maximu...

Lab - on - a - Chip Technology —

Hybridoma: On-chip Cell Fusion Lab in a Tube Lab on a Chip

Antibodies have been used for many different applications ranging from basic biological studies to therapeutics. For example, antibodies are used in treatments as wide ranging as cancer care, autoimmune disease therapy, and to prevent rejection of transplanted organs. This requires large quantities of antibodies, which can be supplied via hybridoma generation. Hybridomas are hybrid cell lines f...